The benefits of anti-seize are really two fold, and especially beneficial to an application with four threads in the cylinder heads. Primarily, it is the function of anti-seize to prevent gavanic corrosion or galvanic galling of disimilar metallic components held in close tolerance. However, anti-seize has been proven to work very well as a heat-sink compound where the heat from the plug can be more easily transferred to the cylinder head and cooling passages. Since 4 thread heads do provide limited heat transfer, increasing the capabilty of heat transfer in this application is beneficial to say the least.
Cheers,
PARKER